This study presents a stress analysis of hybrid plating constructions on femur fracture. The bone screw mounting configurations have successfully modeled with ANSYS Multiphysics/LS-Dyna v.18.1. The bone model was achieved from the CT-scanning of the human femur bone. The interactions between femur bone and hybrid plating were observed. Locking compression plates with 8 holes for bone screws were used. Applied axial compression load has developed stress distribution at all segments. Locking screws endured the bending forces and generated bending moment. Stress concentrations were noticeable at the screws neck. Nonlocking screws have produced a lower stress but bearing to be loosed since has small angular rigidity due to unthreaded screw heads. The most stable bone screw configuration was model A with N-L-N-L L-N-L-N pattern. The alternating sequence of screw configuration resulted in lower stress distribution at all segments, has small screw displacements and enduring lowest stress at each segment, especially femur bone.