The article deals with the issues of modification and optimization of the manipulation process using a collaborative robot Fanuc in the RobotGuide environment. The collaborative robot is equipped with a combined effector containing two double-jaw pneumatic grippers and a vacuum effector. The robot performs the manipulation process based on the selection via the operating touch panel, where it is possible to choose from eight options. The workplace uses a working area of 1500x1300 mm. By implementing the optimization of the robotic cell, a reduction in working time by more than 20% was achieved.