The article builds on the Euro-CASE Policy Paper published in 2013 on “Transforming Manufacturing’ A path to a Smart, Sustainable and Inclusive growth in Europe” [Euro-CASE 2013]. The industry is a very significant sector of the economy in the Czech Republic, it is crucial to follow new industry challenges as the upcoming digital revolution enables connectivity, automation, robotization etc. with the potential to change the productive structure and reorganise the value creation increasingly around digital platform ecosystems. Digital platforms refer to a technology-enabled business model that facilitates exchanges between multiple agents and offers a value that is proportional to the size and the quality of the engaged community. The exponential change of technology development and the globalization challenge the structure of production and manufacturing not only in the Czech Republic, but also on the European level. The paper raises discussion points on the above mentioned future challenges.