In this study, the authors developed a smart, high power of disinfection machine using IoT technology. This disinfection machine generates super fine fog from H2O2 solution by utilizing pressure-swirl airblast atomizer. This machine sprays the H2O2 fog into the air inside the operating room in hospitals to disinfect and make the environment clean. The operation of the disinfection machine is totally remote controlled via mobile application using Bluetooh Low Energy (BLE) communication technology. All operating parameters are remotely, real time monitored and controlled. In addition, the machine operation history of are fully collected and stored both on a memory card in control circuit board and on cloud database. Furthermore, the heat generation from the integrated circuits (ICs) or chip and electronic components on the control printed circuit board (PCB) is also studied in order to prevent the overheating of the components which cause malfunction or instability of the machine. The results show that the temperature of all the electronic components on the control PCB during working is within the temperature allowance, and the disinfection machine works well.